Poppers, by Inducing HHV-8 Virion Production, Can Act as a Promoter for HHV-8 Transmission in Men Who Have Sex With Men. (31st March 2021)

• Record Type: Journal Article
• Authors: Jary, Aude; Gothland, Adélie; Palich, Romain; Leducq, Valentin; Monsel, Gentiane; Imbert, Sébastien; Schneider, Luminita; Simon, Anne; Spano, Jean-Philippe; Katlama, Christine; Larabi, Islam Amine; Alvarez, Jean-Claude; Calvez, Vincent; Marcelin, Anne-Geneviève
• Is Part Of: Open forum infectious diseases. Volume 8:Number 7(2021)
• Publication Date: 2021-03-31
• Subjects: HHV-8 -- MSM -- HIV PrEP -- poppers -- chemsex -- HHV-8 production; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab166
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Environmental factors were reported to increase the risk of human herpesvirus 8 (HHV-8) transmission. In a population of men who have sex with men (MSM), we found evidence that chemsex was associated with human herpesvirus 8 seropositivity in vivo and that poppers induced HHV-8 virion production in vitro. Our finding may explain the higher HHV-8 transmission in MSM.