Cefiderocol Pharmacokinetics in a Patient Receiving Continuous Venovenous Hemodiafiltration. (25th May 2021)

• Record Type: Journal Article
• Authors: Kobic, Emir; Gill, Christian M; Mochon, A Brian; Nicolasora, Nelson P; Nicolau, David P
• Is Part Of: Open forum infectious diseases. Volume 8:Number 7(2021)
• Publication Date: 2021-05-25
• Subjects: antimicrobial dosing -- cefiderocol -- continuous renal replacement therapy -- CRRT -- CVVHDF -- pharmacodynamics -- pharmacokinetics; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab252
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Antimicrobial dosing in patients receiving continuous renal replacement therapy is a continued clinical challenge. We describe a case of a patient receiving cefiderocol 2 g intravenously every 8 hours as a 3-hour infusion for a multidrug-resistant Pseudomonas aeruginosa pneumonia and bacteremia while undergoing continuous venovenous hemodiafiltration. The clinical course and cefiderocol pharmacokinetics are described.