A radiomics-based model to differentiate glioblastoma from solitary brain metastases. Issue 8 (August 2021)

• Record Type: Journal Article
• Authors: Su, C.-Q.; Chen, X.-T.; Duan, S.-F.; Zhang, J.-X.; You, Y.-P.; Lu, S.-S.; Hong, X.-N.
• Is Part Of: Clinical radiology. Volume 76:Issue 8(2021)
• Page Start: 629.e11
• Page End: 629.e18
• Publication Date: 2021-08
• Subjects: Medical radiology -- Periodicals; Radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiology -- Periodicals; Societies, Medical -- Periodicals; Medical radiology; Radiotherapy; Electronic journals; Periodicals; 616.0757
• DOI: 10.1016/j.crad.2021.04.012
• Languages: English
• ISSNs: 0009-9260

Abstract

Abstract : AIM: To differentiate glioblastoma (GBM) from solitary brain metastases (MET) using radiomic analysis. Materials and methods: Two hundred and fifty-three patients with solitary brain tumours (157 GBM and 98 solitary brain MET) were split into a training cohort ( n= 178) and a validation cohort ( n= 77) by stratified sampling using computer-generated random numbers at a ratio of 7:3. After feature extraction, minimum redundancy maximum relevance (mRMR) and the least absolute shrinkage and selection operator (LASSO) were used to build the radiomics signature on the training cohort and validation cohort. Performance was assessed by radiomics score (Rad-score), receiver operating characteristic (ROC) curve, calibration, and clinical usefulness. RESULTS: Eleven radiomic features were selected as significant features in the training cohort. The Rad-score was significantly associated with the differentiation between GBM and solitary brain MET ( p< 0.001) both in the training and validation cohorts. The radiomics signature yielded area under the curve (AUC) values of 0.82 and 0.81 in the training and validation cohorts to distinguish between GBM and solitary brain MET. CONCLUSIONS: The radiomics model might be a useful supporting tool for the preoperative differentiation of GBM from solitary brain MET, which could aid pretreatment decision-making. Highlights: The differentiation between GBM and solitary MET is a radiological challenge. The Radscore was significant in the differentiation between GBM and solitary MET. The radiomics classifier based on CE-T1WI yielded good performance. The radiomics signature will facilitate the differentiation of GBM from solitary MET.