The porcine accessory carpal bone as a model for biologic joint replacement for trapeziometacarpal osteoarthritis. (15th July 2021)

• Record Type: Journal Article
• Authors: Stoeckl, Brendan D.; Zlotnick, Hannah M.; Farrell, Megan J.; Fryhofer, George W.; Hast, Michael W.; Miller, Liane M.; Sennett, Mackenzie L.; Baxter, Josh R.; Schaer, Thomas P.; Mauck, Robert L.; Steinberg, David R.
• Is Part Of: Acta biomaterialia. Volume 129(2021)
• Page Start: 159
• Page End: 168
• Publication Date: 2021-07-15
• Subjects: Trapeziometacarpal Joint -- Osteoarthritis -- Carpometacarpal Joint -- Large Animal Model -- Biologic Joint Replacement -- Tissue Engineering; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1016/j.actbio.2021.05.011
• Languages: English
• ISSNs: 1742-7061

Abstract

Abstract: Given its complex shape and relatively small size, the trapezium surface at the trapeziometacarpal (TMC) joint is a particularly attractive target for anatomic biologic joint resurfacing, especially given its propensity to develop osteoarthritis, and the limited and sub-optimal treatment options available. For this to advance to clinical translation, however, an appropriate large animal model is required. In this study, we explored the porcine accessory carpal bone (ACB) as a model for the human trapezium. We characterized ACB anatomy, geometry, joint and tissue-scale mechanics, and composition across multiple donors. We showed that the ACB is similar both in size, and in the saddle shape of the main articulating surface to the human trapezium, and that loads experienced across each joint are similar. Using this information, we then devised a fabrication method and workflow to produce patient-specific tissue-engineered replicas based on CT scans, and showed that when such replicas are implanted orthotopically in an ex vivo model, normal loading is restored. Data from this study establish the porcine ACB as a model system in which to evaluate function of engineered living joint resurfacing strategies. Statement of significance: Biologic joint resurfacing, or the replacement of a joint with living tissue as opposed to metal and plastic, is the holy grail of orthopaedic tissue engineering. However, despite marked advances in engineering native-like osteochondral tissues and in matching patient-specific anatomy, these technologies have not yet reached clinical translation. Given its propensity for developing osteoarthritis, as well as its small size and complex shape, the trapezial surface of the trapeziometacarpal joint at the base of the thumb presents a unique opportunity for pursuing a biologic joint resurfacing strategy. This work establishes the porcine accessory carpal bone as an animal model for the human trapezium and presents a viable test-bed for evaluating the function of engineered living joint resurfacing strategies. Graphical abstract: Image, graphical abstract