Exploring the relationship between the dielectric properties and viability of human normal hepatic tissues from 10 Hz to 100 MHz based on grey relational analysis and BP neural network. (July 2021)

• Record Type: Journal Article
• Authors: Wang, Hang; Wang, Lei; Yang, Lin; Shi, Xuetao; Wen, Zhihong; Dong, Xiuzhen
• Is Part Of: Computers in biology and medicine. Volume 134(2021)
• Publication Date: 2021-07
• Subjects: Dielectric properties -- Tissue viability -- Liver -- BP neural Network; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2021.104494
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: Liver is an important parenchyma organ, and its tissue viability plays an important role in liver transplantation and liver ischemic injury assessment. Dielectric property is a useful biophysical feature that provides insights into the structure and composition of biological tissues. This work aims to establish the relationship between the dielectric properties and viability of human normal hepatic tissues and explore the possibility of evaluating tissue viability by using dielectric properties. First, data on dielectric properties and tissue viability (including cell morphology and enzyme indicators) were collected from human liver tissues at 0.25–24 h after isolation. Grey relational analysis was conducted to select dielectric property and tissue viability indices that were highly correlated with prolonged ex vivo time as the inputs and outputs, respectively, of back-propagation (BP) neural network analysis. Finally, a BP neural network was developed with the Levenberg–Marquardt algorithm to explore the possibility of using dielectric properties as the basis for tissue viability evaluation. Results showed that the mean relative error for prediction was 2.40%, indicating that the model showed potential in forecasting liver tissue viability by applying dielectric properties. Highlights: Dielectric property is closely related to the physiological state of the tissue. Relationship established through grey relational analysis and BP neural network. Human normal liver tissue viability can be assessed by dielectric properties. The change in cell morphology directly influences the dielectric properties.