Progressive microstructural alterations in subcortical nuclei in Parkinson's disease: A diffusion magnetic resonance imaging study. (July 2021)

• Record Type: Journal Article
• Authors: Bai, Xueqin; Zhou, Cheng; Guo, Tao; Guan, Xiaojun; Wu, Jingjing; Liu, Xiaocao; Gao, Ting; Gu, Luyan; Xuan, Min; Gu, Quanquan; Huang, Peiyu; Song, Zhe; Yan, Yaping; Pu, Jiali; Zhang, Baorong; Xu, Xiaojun; Zhang, Minming
• Is Part Of: Parkinsonism & related disorders. Volume 88(2021)
• Page Start: 82
• Page End: 89
• Publication Date: 2021-07
• Subjects: Parkinson's disease -- Diffusion kurtosis imaging -- Tensor imaging -- Disease stage -- Subcortical nuclei; AD Axial diffusivity -- AK Axial kurtosis -- AUC Area under curve -- DKI Diffusion kurtosis imaging -- DTI Diffusion tensor imaging -- EPD Early-stage Parkinson's disease -- FA Fractional anisotropy -- GP Globus pallidus -- HC Healthy controls -- MD Mean diffusivity -- MLPD Moderate-late-stage Parkinson's disease -- MK Mean kurtosis -- PD Parkinson's disease -- RD Radial diffusivity -- RK Radial kurtosis -- ROC Receiver operating characteristic -- SN Substantia nigra; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2021.06.003
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Objectives: To explore the microstructural alterations in subcortical nuclei in Parkinson's disease (PD) at different stages with diffusion kurtosis imaging (DKI) and tensor imaging and to test the performance of diffusion metrics in identifying PD. Methods: 108 PD patients (64 patients in early-stage PD group (EPD) and 44 patients in moderate-late-stage PD group (MLPD)) and 64 healthy controls (HC) were included. Tensor and kurtosis metrics in the subcortical nuclei were compared. Partial correlation was used to correlate the diffusion metrics and Unified Parkinson's Disease Rating Scale part-III (UPDRS-III) score. Logistic regression and receiver operating characteristic analysis were applied to test the diagnostic performance of the diffusion metrics. Results: Compared with HC, both EPD and MLPD patients showed higher fractional anisotropy and axial diffusivity, lower mean kurtosis (MK) and axial kurtosis in substantia nigra, lower MK and radial kurtosis (RK) in globus pallidus (GP) and thalamus (all p < 0.05). Compared with EPD, MLPD patients showed lower MK and RK in GP and thalamus (all p < 0.05). MK and RK in GP and thalamus were negatively correlated with UPDRS-III score (all p < 0.01). The logistic regression model combining kurtosis and tensor metrics showed the best performance in diagnosing PD, EPD, and MLPD (areas under curve were 0.817, 0.769, and 0.914, respectively). Conclusions: PD has progressive microstructural alterations in the subcortical nuclei. DKI is sensitive to detect microstructural alterations in GP and thalamus during PD progression. Combining kurtosis and tensor metrics can achieve a good performance in diagnosing PD. Highlights: PD has progressive microstructural alterations in the subcortical nuclei. DKI is sensitive in detecting microstructural changes in GP and thalamus during PD progression. The combination of kurtosis and tensor metrics can achieve a good performance in diagnosing PD.