Evaluation of human cartilage endplate composition using MRI: Spatial variation, association with adjacent disc degeneration, and in vivo repeatability. Issue 7 (7th July 2020)

• Record Type: Journal Article
• Authors: Wang, Linshanshan; Han, Misung; Wong, Jason; Zheng, Patricia; Lazar, Ann A.; Krug, Roland; Fields, Aaron J.
• Is Part Of: Journal of orthopaedic research. Volume 39:Issue 7(2021)
• Page Start: 1470
• Page End: 1478
• Publication Date: 2020-07-07
• Subjects: cartilage endplate -- intervertebral disc degeneration -- low back pain -- magnetic resonance imaging (MRI) -- T2*; Orthopedics -- Periodicals; Musculoskeletal system -- Periodicals; 616.7
• DOI: 10.1002/jor.24787
• Languages: English
• ISSNs: 0736-0266

Abstract

Abstract: Cartilage endplate (CEP) biochemical composition may influence disc degeneration and regeneration. However, evaluating CEP composition in patients remains a challenge. We used T2* mapping from ultrashort echo‐time (UTE) magnetic resonance imaging (MRI), which is sensitive to CEP hydration, to investigate spatial variations in CEP T2* values and to determine how CEP T2* values correlate with adjacent disc degeneration. Thirteen human cadavers (56.4 ± 12.7 years) and seven volunteers (36.9 ± 10.9 years) underwent 3T MRI, including UTE and T1ρ mapping sequences. Spatial mappings of T2* values in L4‐S1 CEPs were generated from UTE images and compared between subregions. In the abutting discs, mean T1ρ values in the nucleus pulposus were compared between CEPs with high vs low T2* values. To assess in vivo repeatability, precision errors in mean T2* values, and intraclass correlation coefficients (ICC) were measured from repeat scans. Results showed that CEP T2* values were highest centrally and lowest posteriorly. In the youngest individuals (<50 years), who had mild‐to‐moderately degenerated Pfirrmann grade II‐III discs, low CEP T2* values associated with severer disc degeneration: T1ρ values were 26.7% lower in subjects with low CEP T2* values ( P = .025). In older individuals, CEP T2* values did not associate with disc degeneration ( P = .39‐.62). Precision errors in T2* ranged from 1.7 to 2.6 ms, and reliability was good‐to‐excellent (ICC = 0.89‐0.94). These findings suggest that deficits in CEP composition, as indicated by low T2* values, associate with severer disc degeneration during the mild‐to‐moderate stages. Measuring CEP T2* values with UTE MRI may clarify the role of CEP composition in patients with mild‐to‐moderate disc degeneration.