Adjustment by hematocrit level in calculation of removal rate in therapeutic apheresis. Issue 4 (2nd May 2021)

• Record Type: Journal Article
• Authors: Sakurasawa, Takatoshi; Ohkubo, Atsushi; Hoshikawa, Yuki; Yamauchi, Daisuke; Yamamoto, Hiroko; Seshima, Hiroshi; Kurashima, Naoki; Iimori, Soichiro; Rai, Tatemitsu; Uchida, Shinichi; Naito, Shotaro
• Is Part Of: Therapeutic apheresis and dialysis. Volume 25:Issue 4(2021)
• Page Start: 425
• Page End: 431
• Publication Date: 2021-05-02
• Subjects: blood component removal -- hemostatics -- immunoglobulins -- plasma exchange; Hemapheresis -- Periodicals; Dialysis -- Periodicals; Blood Component Removal -- Periodicals; Renal Dialysis -- Periodicals; Hémaphérèse -- Périodiques; Dialyse -- Périodiques; Sang -- Collecte et conservation -- Périodiques; 616
• DOI: 10.1111/1744-9987.13660
• Languages: English
• ISSNs: 1744-9979

Abstract

Abstract: Plasma volume (PV) variation during therapeutic apheresis (TA) (such as plasma exchange [PE] and selective PE using albumin solution as replacement solution or immunoadsorption plasmapheresis) has been considered to be unignorable. It changes the concentration of the target molecule and might impact its removal rate (RR.) This study aimed to evaluate the effects of PV variation on the calculation of the RR of fibrinogen and immunoglobulin by categorizing the hematocrit (Ht) change during TA into two patterns, that is, increased group and decreased group. In all modalities of TA, the Ht level frequently changed during apheresis sessions. In calculating RR, RR calculated with Ht adjustment was significantly higher than that calculated without adjustment in the increased group and significantly lower than it in the decreased group. Therefore, RR might have been underestimated in the increased group and overestimated in the decreased group when RR was calculated without Ht adjustment. Ht adjustment is suggested to be crucial in calculating RR in TA.