Cover Feature: First Total Synthesis of Phytoprostanes with Prostaglandin‐Like Configuration, Evidence for Their Formation in Edible Vegetable Oils and Orienting Study of Their Biological Activity (Chem. Eur. J. 37/2021). Issue 37 (9th June 2021)

• Record Type: Journal Article
• Authors: Smrček, Jakub; Hájek, Miroslav; Hodek, Ondřej; Čížek, Karel; Pohl, Radek; Jahn, Emanuela; Galano, Jean‐Marie; Oger, Camille; Durand, Thierry; Cvačka, Josef; Jahn, Ullrich
• Is Part Of: Chemistry. Volume 27:Issue 37(2021)
• Page Start: 9464
• Page End: 9464
• Publication Date: 2021-06-09
• Subjects: oxidative stress -- phytoglandin -- phytoprostane -- total synthesis -- vegetable oil; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202101937
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Phytoglandins from the reaction flask enable their identification in Nature. Hypothetical plant‐based prostaglandin analogs were obtained by a 15‐step asymmetric total synthesis. They were applied as an analytical standard in a detailed LC‐MS/MS study confirming phytoglandin formation in autoxidized linolenic acid and in various edible vegetable oils in sizeable quantities. More information can be found in the Full Paper by U. Jahn et al. (DOI: 10.1002/chem.202100872 ).