Extrahepatic biliary obstruction can interfere with hepatic fibrosis prediction using two‐dimensional shear wave elastography in dogs. Issue 4 (14th April 2021)

• Record Type: Journal Article
• Authors: Tamura, Masahiro; Ohta, Hiroshi; Osuga, Tatsuyuki; Sasaki, Noboru; Morishita, Keitaro; Takiguchi, Mitsuyoshi
• Is Part Of: Veterinary radiology & ultrasound. Volume 62:Issue 4(2021)
• Page Start: 483
• Page End: 489
• Publication Date: 2021-04-14
• Subjects: acoustic radiation force impulse -- canine -- icterus -- jaundice -- viscosity; Veterinary radiology -- Periodicals; Radiologie vétérinaire -- Périodiques; Échographie vétérinaire -- Périodiques; Radiography -- Periodicals; Ultrasonography -- Periodicals; Diagnosis -- Periodicals; Veterinary Medicine -- Periodicals; Societies, Medical -- Periodicals; 636.089607
• DOI: 10.1111/vru.12969
• Languages: English
• ISSNs: 1058-8183

Abstract

Abstract: Two‐dimensional shear wave elastography (2D‐SWE) can be used to quantitatively evaluate the elastic modulus of the liver as shear wave velocity (SWV), which can noninvasively predict clinically relevant hepatic fibrosis in both dogs and humans. However, extrahepatic biliary obstruction (EHBO), regardless of the presence of clinically relevant hepatic fibrosis, can influence SWVs in humans and thus may interfere with hepatic fibrosis prediction using 2D‐SWE in dogs. The aim of this prospective, observational, and one‐group pretest–posttest study is to investigate whether SWV measured by 2D‐SWE displays a difference between dogs with and without EHBO. A total of 20 dogs were included (7 with EHBO and 13 with gallbladder pathology but no EHBO) that underwent preoperative SWV measurement using 2D‐SWE. In all dogs, stages of hepatic fibrosis were evaluated histopathologically using a scoring scheme. In addition, postoperative SWVs in dogs with EHBO relieved via laparotomy were also evaluated. The median (range) SWVs in the dogs with and without EHBO were 1.91 (1.81–2.54) m/s and 1.57 (1.37–1.64) m/s, respectively. Although there was no significant difference in the histopathological hepatic fibrosis stages between the dogs with and without EHBO, the preoperative SWVs in the dogs with EHBO were significantly higher than in dogs without EHBO ( P = .0004), and SWVs were found to decrease significantly after surgery ( P = .0097). This study demonstrates that EHBO can increase the SWV of dogs without clinically relevant hepatic fibrosis and can interfere with the prediction of noninvasive hepatic fibrosis using 2D‐SWE.