Modified setting of negative pressure in children with mild respiratory disease. Issue 7 (12th June 2021)

• Record Type: Journal Article
• Authors: Ishimori, Shingo; Nagase, Shizuka; Kanagawa, Atsuko; Nakajiri, Tomoshi; Okita, Sora; Oyazato, Yoshinobu; Nishiyama, Atsushi; Yonetani, Masahiko
• Is Part Of: Pediatrics international. Volume 63:Issue 7(2021)
• Page Start: 838
• Page End: 844
• Publication Date: 2021-06-12
• Subjects: acute respiratory distress -- chest‐wall retraction -- children -- continuous negative extra‐thoracic pressure -- negative pressure ventilation; Pediatrics -- Periodicals; 618.92
• DOI: 10.1111/ped.14560
• Languages: English
• ISSNs: 1328-8067

Abstract

Abstract: Background: Continuous negative extra‐thoracic pressure (CNEP) can prevent children with apnea developing severe respiratory infection with endotracheal intubation. Little is known about children with mild acute respiratory disease, especially with a focus on clinical respiratory symptoms. Methods: We conducted a prospective, observational study between July 2014 and July 2017 to evaluate the safety of a modified setting of CNEP in hospitalized children with symptoms of chest‐wall retraction or nasal alar breathing without the requirement for immediate intubation therapy in a single center. A modified setting of CNEP was defined as 4 h of treatment comprising 3 consecutive hours of CNEP followed by 1 h of rest. Results: We studied 19 hospitalized children with retraction or nasal breathing but no possible state of endotracheal intubation. The median age at admission was 0.9 years and the duration of CNEP was 6 days. No sedative drugs were used. The percentage of children with retraction or nasal breathing after 24 h from initiation of CNEP was significantly decreased compared with that just before CNEP (68% vs 100%, P = 0.02). Logistic regression showed no statistical evidence of contributing factors for pulmonary symptoms. No patients were transferred to receive intubation, but one boy reinitiated respiratory support within 6 months after discharge. No children had adverse events of upper airway obstruction, skin injury, interfering with access, hypothermia, discomfort from fitting a cuirass, and neck excoriation. Conclusions: Our results suggest that a modified setting of CNEP management can be tolerated and continued without concern of adverse events.