Investigation and comparison of biological effects of regioselectively synthesized thiazole derivatives. (28th April 2021)

• Record Type: Journal Article
• Authors: Moghaddam‐manesh, Mohammadreza; Beyzaei, Hamid; Heidari Majd, Mostafa; Hosseinzadegan, Sara; Ghazvini, Kiarash
• Is Part Of: Journal of heterocyclic chemistry. Volume 58:Number 7(2021)
• Page Start: 1525
• Page End: 1530
• Publication Date: 2021-04-28
• Subjects: antibacterial activity -- antibiotic‐resistant Escherichia coli -- anticancer assay -- antifungal pproperty -- antioxidant potential -- Thiazole; Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.4278
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract: In this study, anticancer, antibacterial (against hospital‐isolated antibiotic‐resistant Escherichia coli strains), antifungal, and antioxidant effects of synthesized heterocyclic compounds 5 and 7 containing thiazole core were examined. Cytotoxicity testing was utilized against MCF‐7 breast cancer cells via MTT cell viability assay. Antibacterial and antifungal activities were checked out according to Clinical and Laboratory Standards Institute (CLSI) guidelines, and antioxidant properties were evaluated through scavenging 2, 2‐diphenyl‐1‐picrylhydrazyl (DPPH) free radicals. Results showed the viability of breast cancer cell lines was reliant on concentration of heterocycles and time of incubation. Synthetic compounds exhibited excellent antibacterial and antifungal properties base on their minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC) values as well as high antioxidant activities according to their IC50 values. Higher anticancer and antibacterial properties were observed with compound 7; on the contrary, thiazole 5 had better antioxidant effects. They can be introduced as potent antimicrobial, antioxidant, and anticancer agents. Abstract :