Comparison of myoglobin clearance in three types of blood purification modalities. Issue 4 (7th May 2021)

• Record Type: Journal Article
• Authors: Suzuki, Shinya; Moriyama, Kazuhiro; Hara, Yoshitaka; Hinoue, Takuya; Kato, Yu; Hasegawa, Daisuke; Kuriyama, Naohide; Nakamura, Tomoyuki; Komatsu, Satoshi; Yamashita, Chizuru; Komura, Hidefumi; Nishida, Osamu
• Is Part Of: Therapeutic apheresis and dialysis. Volume 25:Issue 4(2021)
• Page Start: 401
• Page End: 406
• Publication Date: 2021-05-07
• Subjects: hemofiltration -- modality -- myoglobin -- polyacrylonitrile -- polymethylmethacrylate; Hemapheresis -- Periodicals; Dialysis -- Periodicals; Blood Component Removal -- Periodicals; Renal Dialysis -- Periodicals; Hémaphérèse -- Périodiques; Dialyse -- Périodiques; Sang -- Collecte et conservation -- Périodiques; 616
• DOI: 10.1111/1744-9987.13657
• Languages: English
• ISSNs: 1744-9979

Abstract

Abstract: Myoglobin, which can cause acute kidney injury, has a relatively high molecular weight and is poorly cleared by diffusion. We compared and examined myoglobin clearance by changing the blood purification membrane and modality in patients with a myoglobin blood concentration ≥ 1000 ng/ml. We retrospectively analyzed three patient groups based on the following three types of continuous hemofiltration (CHF): AN69ST membrane, polymethylmethacrylate (PMMA) membrane, and high‐flow hemodiafiltration (HDF) with increased dialysate flow rate using the PMMA membrane. There was no significant difference in clearance in CHF between AN69ST and PMMA membranes. However, the high‐flow HDF group showed the highest myoglobin clearance ( p = 0.003). In the PMMA membrane, changing the treatment modality to high‐flow HDF increased clearance above the theoretical value, possibly due to internal filtration. To remove myoglobin by kidney replacement therapy from patients with hypermyoglobinemia, a modality such as high‐flow HDF would be desirable.