Application of animal experimental models in the research of schizophrenia. Issue 4 (22nd June 2021)

• Record Type: Journal Article
• Authors: Wang, Pengjie; Li, Manling; Zhao, Aizhen; Ma, Jie
• Is Part Of: American journal of medical genetics. Volume 186:Issue 4(2021)
• Page Start: 209
• Page End: 227
• Publication Date: 2021-06-22
• Subjects: animal experimental model -- behavioral phenotype -- biological mechanism -- schizophrenia; Neuropsychiatry -- Periodicals; Medical genetics -- Periodicals; 616.8904205
• DOI: 10.1002/ajmg.b.32863
• Languages: English
• ISSNs: 1552-4841

Abstract

Abstract: Schizophrenia is a relatively common but serious mental illness that results in a heavy burden to patients, their families, and society. The disease can be triggered by multiple factors, while the specific pathogenesis remains unclear. The development of effective therapeutic drugs for schizophrenia relies on a comprehensive understanding of the basic biology and pathophysiology of the disease. Therefore, effective animal experimental models play a vital role in the study of schizophrenia. Based on different molecular mechanisms and modeling methods, the currently used experimental animal experimental models of schizophrenia can be divided into four categories that can better simulate the clinical symptoms and the interplay between susceptible genes and the environment: neurodevelopmental, drug‐induced, genetic‐engineering, and genetic‐environmental interaction of animal experimental models. Each of these categories contains multiple subtypes, which has its own advantages and disadvantages and therefore requires careful selection in a research application. The emergence and utilization of these models are promising in the prediction of the risk of schizophrenia at the molecular level, which will shed light on effective and targeted treatment at the genetic level.