Steroidal constituents isolated from the seeds of Withania somnifera. Issue 13 (15th June 2021)

• Record Type: Journal Article
• Authors: Iguchi, Tomoki; Kuroda, Minpei; Ishihara, Mai; Sakagami, Hiroshi; Mimaki, Yoshihiro
• Is Part Of: Natural product research. Volume 35:Issue 13(2021)
• Page Start: 2205
• Page End: 2210
• Publication Date: 2021-06-15
• Subjects: Withania somnifera -- Solanaceae -- seed -- withanolide glycoside -- ergostanol glycoside -- furostanol glycoside -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1667351
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new withanolide glycoside (1 ), two new ergostanol glycosides (2 and 3 ), and a new furostanol glycoside (4 ), along with nine known steroidal derivatives (5 –12 ) were isolated from the seeds of Withania somnifera . The structures of the new compounds were determined using spectroscopic analysis and hydrolysis. The cytotoxic activities of the isolated compounds were evaluated against Ca9-22 human gingival carcinoma cells, HSC-2 human mouth carcinoma cells, and HL-60 human promyelocytic leukemia cells. Only 12 exhibited cytotoxic activity against these cell lines with IC50 values of 0.38, 0.54, and 1.5 μM, respectively. Graphical Abstract: UF0001