Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro. Issue 13 (15th June 2021)

• Record Type: Journal Article
• Authors: Simonovic, Mladen; Kojic, Vesna; Jakimov, Dimitar; Glumac, Miodrag; Pejin, Boris
• Is Part Of: Natural product research. Volume 35:Issue 13(2021)
• Page Start: 2253
• Page End: 2256
• Publication Date: 2021-06-15
• Subjects: Soft fruit -- extract -- phenolics -- A-549 cells -- MRC-5 cells -- comet assay -- ROS; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1666391
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: This study was focused on in vitro cytotoxicity screening of the raspberry seeds methanol extract towards a number of cancer cell lines of human origin. The tested extract at the preferred concentrations (IC50 <30 µg/mL) inhibited only the growth of the lung cancer A-549 cells (IC50 = 14.07 ± 0.96 µg/mL). At the same time, it was practically inactive (IC50 >300 µg/mL) and non-mutagenic towards normal MRC-5 lung cells. Finally, the extract potently scavenged both OH· (IC50 = 20.11 ± 1.77 µg/mL) and O 2- · (IC50 = 47.23 ± 3.82 µg/mL), the free radicals of proved relevance for cancer pathophysiology. Though seeds were enriched with phenolic compounds (TPC = 5.21 ± 0.07 mg GAE/g), anthocyanins were present in traces only (TAC = 0.07 ± 0.003 mg cyn-3-glu/g), while flavonoids were not detected at all. This is the first report on anti-lung cancer potential of the seeds of any soft fruit. Graphical Abstract: UF0001