Cascade catalytic nanoplatform constructed by laterally-functionalized pillar[5]arenes for antibacterial chemodynamic therapy. Issue 25 (17th June 2021)

• Record Type: Journal Article
• Authors: Li, Fei; Zang, Mingsong; Hou, Jinxing; Luo, Quan; Yu, Shuangjiang; Sun, Hongcheng; Xu, Jiayun; Liu, Junqiu
• Is Part Of: Journal of materials chemistry. Volume 9:Issue 25(2021)
• Page Start: 5069
• Page End: 5075
• Publication Date: 2021-06-17
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d1tb00868d
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A cascade catalytic nanoplatform was established for effective chemodynamic antibacterial therapy. Abstract : Chemodynamic therapy (CDT) is an emerging approach to overcome bacterial infections that can efficiently convert hydrogen peroxide (H2 O2 ) to generate highly toxic hydroxyl radicals (˙OH). How to develop safe and effective CDT-based strategies is in high demand but challenging. Herein, a cascade catalytic nanoplatform (GOx–NCs/Fe3 O4 ) was designed by absorbing glucose oxidase (GOx) onto the surface of covalent-assembled polymer capsules (NCs) encapsulating Fe3 O4 nanoparticles. With the presence of glucose, GOx could effectively catalyze it to produce H2 O2 and result in a decrease in pH value, both of which would assist the subsequent Fenton reaction. Encapsulated Fe3 O4 nanoparticles would subsequently trigger H2 O2 to produce ˙OH, which could make antibacterial CDT come true. More importantly, the polymer capsules exhibited little to no cytotoxicity towards mammalian cells, which might provide more opportunities and potential to apply in other fields.