Sprinkling salt on mitochondria: The metabolic and pathophysiological roles of mitochondrial Na+ signaling mediated by NCLX. (July 2021)

• Record Type: Journal Article
• Authors: Assali, Essam A.; Sekler, Israel
• Is Part Of: Cell calcium. Volume 97(2021)
• Publication Date: 2021-07
• Subjects: NCLX -- Mitochondrial Ca2+ efflux -- Na+ signaling -- Hypoxia -- Ischemia; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2021.102416
• Languages: English
• ISSNs: 0143-4160

Abstract

Graphical abstract: Highlights: The mitochondrial Na + /Ca 2+, NCLX emerged recently to be a pro-survival protein, preventing mitochondrial Ca 2+ overload and cell death. NCLX is the major entry pathway for Na + into the mitochondria. Na + mitochondrial influx, mediated by NCLX, modulate mitochondrial metabolic activity. Recent studies suggest a potential harmful route of NCLX activity by permitting mitochondrial Na + toxicity and impairing cell metabolic activity. Abstract: NCLX, the mitochondrial Na + /Ca 2+ transporter is a key player in Ca 2+ signaling. However, its role in Na + signaling is poorly understood. In this review we focus on Na + signaling by NCLX, and discuss recent physiological and pathophysiological roles attributed to the Na + influx into mitochondria.