Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918. Issue 6 (June 2021)

• Record Type: Journal Article
• Authors: Stott, Lisa A.; Brighton, Cheryl A.; Brown, Jason; Mould, Richard; Bennett, Kirstie A.; Newman, Robert; Currinn, Heather; Autore, Flavia; Higueruelo, Alicia P.; Tehan, Benjamin G.; MacSweeney, Cliona; O'Brien, Michael A.; Watson, Steve P.
• Is Part Of: Heliyon. Volume 7:Issue 6(2021)
• Publication Date: 2021-06
• Subjects: GPR52 -- Inverse agonist -- Cannabidiol -- CBD -- O-1918; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2021.e07201
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy. Abstract : GPR52, Inverse agonist, Cannabidiol, CBD, O-1918.