Black chokeberry (Aronia melanocarpa) extracts in terms of geroprotector criteria. (August 2021) - Platonova, Elena Y.
Abstract: Background: Black chokeberry ( Aronia melanocarpa (Micht.) Elliot) is a great dietary source of a wide range of biologically active compounds, such as anthocyanins, flavonoids, other phenolic compounds, vitamins, and minerals that have a wide range of health benefits. Scope and approach: Here we provide an overview of the in vitro and in vivo effects of A. melanocarpa extracts to reveal its potential anti-aging properties in terms of meeting the criteria for a geroprotector. The possible mechanisms of the anti-aging action of black chokeberry extracts are highlighted. Key findings and conclusions: A. melanocarpa extract exhibit geroprotective activity like lifespan extension, anti-proliferative activity, improvement of glucose and lipid metabolism, amelioration of neurodegenerative disorders, antiviral and antibacterial activity, protection of the gastrointestinal system. The mechanisms of A. melanocarpa anti-aging action may be associated with the hormesis effect, activation of antioxidant-defense, modulation of insulin/IGF-1 signaling, and anti-inflammatory activity. Highlights: A. melanocarpa is a rich source of polyphenols with versatile health benefits. Aronia has geroprotective potential due to the hormetic effect of phytochemicals. The anti-aging effect is linked with activation of stress response mechanisms. Potential adverse effects of polyphenols should be taken into account.