ANO5 in membrane repair - Status: "It's complicated". (July 2021)

• Record Type: Journal Article
• Authors: Gerke, Volker; Rescher, Ursula
• Is Part Of: Cell calcium. Volume 97(2021)
• Publication Date: 2021-07
• Subjects: Muscle cell -- Muscular dystropy -- Sarcolemma repair -- Calcium-activated chloride channel -- Anoctamin 5 -- Annexins; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2021.102415
• Languages: English
• ISSNs: 0143-4160

Abstract

Highlights: Anoctamin 5 (ANO5/TMEM16E) gene mutations are associated with skeletal muscle diseases ANO5 belongs to the anoctamin protein family that includes calcium-activated chloride channels ANO5-deficient cells are defective in Ca 2+ -dependent plasma membrane repair of muscle cells ANO5 could be a pharmaceutical target for treatment of ANO5-related muscle diseases Graphical abstract: Abstract: ANO5/TMEM16E gene mutations are associated with myopathies. Two recent publications in the Journal of Cell Biology now both confirm that ANO5 deficiency results in defective plasma membrane repair and Ca 2+ overload. But the big question is whether ANO5 acts at the plasma membrane or the endoplasmic reticulum.