IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis. (23rd May 2021)

• Record Type: Journal Article
• Authors: Turnbull, Isaiah R; Mazer, Monty B; Hoofnagle, Mark H; Kirby, John P; Leonard, Jennifer M; Mejia-Chew, Carlos; Spec, Andrej; Blood, Jane; Miles, Sydney M; Ransom, Eric M; Potter, Robert F; Gaut, Joseph P; Remy, Kenneth E; Hotchkiss, Richard S
• Is Part Of: Open forum infectious diseases. Volume 8:Number 6(2021)
• Publication Date: 2021-05-23
• Subjects: fungal infection -- immunotherapy -- interleukin-7 -- Trichosporon -- wound infection; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab256
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.