A pH-responsive mesoporous silica nanoparticles-based drug delivery system with controlled release of andrographolide for OA treatment. Issue 4 (30th June 2021)

• Record Type: Journal Article
• Authors: He, Mingwei; Qin, Zainen; Liang, Xiaonan; He, Xixi; Zhu, Bikang; Lu, Zhenhui; Wei, Qingjun; Zheng, Li
• Is Part Of: Regenerative biomaterials. Volume 8:Issue 4(2021)
• Publication Date: 2021-06-30
• Subjects: Osteoarthritis -- mesoporous silica nanoparticles -- polyacrylic acid -- pH-response -- andrographolide; Biomedical materials -- Periodicals; Regenerative medicine -- Periodicals; 610.284
• DOI: 10.1093/rb/rbab020
• Languages: English
• ISSNs: 2056-3418

Abstract

Abstract: Andrographolide (AG) has favorable anti-inflammatory and antioxidative capacity. However, it has low bioavailability due to high lipophilicity and can be easily cleared by the synovial fluid after intra-articular injection, leading to low therapeutic efficiency in osteoarthritis (OA). Herein, we designed a nano-sized pH-responsive drug delivery system (DDS) for OA treatment by using modified mesoporous silica nanoparticles (MSNs) with pH-responsive polyacrylic acid (PAA) for loading of AG to form AG@MSNs-PAA nanoplatform. The nanoparticles have uniform size (∼120 nm), high drug loading efficiency (22.38 ± 0.71%) and pH-responsive properties, beneficial to sustained release in OA environment. Compared with AG, AG@MSNs-PAA showed enhanced antiarthritic efficacy and chondro-protective capacity based on IL-1β-stimulated chondrocytes and anterior cruciate ligament transection-induced rat OA model, as demonstrated by lower expression of inflammatory factors and better prevention of proteoglycan loss. Therefore, the AG@MSNs-PAA nanoplatform may be developed as a promising OA-specific and on-demand DDS.