Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants' Nasopharynx: A Randomized Controlled Trial. (23rd May 2020)

• Record Type: Journal Article
• Authors: Bojang, Abdoulie; Baines, Sarah L; Camara, Bully; Guerillot, Romain; Donovan, Liam; Marqués, Raquel Sánchez; Secka, Ousman; D'Alessandro, Umberto; Bottomley, Christian; Howden, Benjamin P; Roca, Anna
• Is Part Of: Clinical infectious diseases. Volume 71:Number 12(2020)
• Page Start: 3222
• Page End: 3225
• Publication Date: 2020-05-23
• Subjects: azithromycin -- ermC -- msr(A) -- NPS -- The Gambia; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa609
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associated in the nasopharynx. Clinical Trials Registration: NCT1800942.