Nanomaterials multifunctional behavior for enlightened cancer therapeutics. (February 2021)

• Record Type: Journal Article
• Authors: Raju, Ganji Seeta Rama; Dariya, Begum; Mungamuri, Sathish Kumar; Chalikonda, Gayathri; Kang, Sung-Min; Khan, Ishaq N.; Sushma, Pinninti Santosh; Nagaraju, Ganji Purnachandra; Pavitra, Eluri; Han, Young-Kyu
• Is Part Of: Seminars in cancer biology. Volume 69(2021)
• Page Start: 178
• Page End: 189
• Publication Date: 2021-02
• Subjects: CNTs carbon nanotubes -- CuS copper sulfide -- EPR enhanced permeability and retention -- GALA glutamic acid-alanine-leucine-alanine -- GSH glutathionine -- AuNPs gold nanoparticles -- MRI magnetic resonance imagining -- MSNPs mesoporous silica nanoparticles -- NPs nanoparticles -- NIR near infrared -- PLA2 phospholipases A2 -- PA photoacoustic -- PHBV poly (3-hydroxybutyrate-co-3-hydroxyvalerate) -- PLGA poly(lactic-co-glycolic acid) -- PAMAM polyamidoamine -- PEG polyethylene glycol -- PM polymeric micelles -- QDs quantum dots -- ROS reactive oxygen species -- AgNPs silver nanoparticles -- siRNA small-interfering RNAs -- SPIONs superparamagnetic iron oxide nanoparticles -- TAM tumor associated macrophage; Nanoparticles -- Quantum dots -- Drug delivery -- Cancer therapy; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2019.08.013
• Languages: English
• ISSNs: 1044-579X

Abstract

Highlights: Different types of nanoparticles and their properties are reviewed. Various nanoparticle drug delivery systems are discussed. Internal and external stimuli-responsive systems are explored. Nanoparticles and their applications in cancer therapy are described. Abstract: Cancer is an outrageous disease with uncontrolled differentiation, growth, and migration to the other parts of the body. It is the second-most common cause of death both in the U.S. and worldwide. Current conventional therapies, though much improved and with better prognosis, have several limitations. Chemotherapeutic agents, for instance, are cytotoxic to both tumor and healthy cells, and the non-specific distribution of drugs at tumor sites limits the dose administered. Nanotechnology, which evolved from the coalescence and union of varied scientific disciplines, is a novel science that has been the focus of much research. This technology is generating more effective cancer therapies to overcome biomedical and biophysical barriers against standard interventions in the body; its unique magnetic, electrical, and structural properties make it a promising tool. This article reviews endogenous- and exogenous-based stimulus-responsive drug delivery systems designed to overcome the limitations of conventional therapies. The article also summarizes the study of nanomaterials, including polymeric, gold, silver, magnetic, and quantum dot nanoparticles. Though an array of drug delivery systems has so far been proposed, there remain many challenges and concerns that should be addressed in order to fill the gaps in the field. Prominence is given to drug delivery systems that employ external- and internal-based stimuli and that are emerging as promising tools for cancer therapeutics in clinical settings.