Metal-free regioselective C–H amination for the synthesis of pyrazole-containing 2H-indazoles. Issue 8 (8th February 2021)

• Record Type: Journal Article
• Authors: Wang, Kai; Wei, Tingting; Zhang, Yujia; Hou, Jiahao; Bai, Renren; Xie, Yuanyuan
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 8(2021)
• Page Start: 1787
• Page End: 1794
• Publication Date: 2021-02-08
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob02485f
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Herein, two different pathways for the synthesis of pyrazole-containing 2 H -indazoles under the oxidation of K2 S2 O8 were reported, affording the desired product in good to excellent yields. And a radical process was included in this transformation. Abstract : A general and practical regioselective approach for the C–H amination of 2 H -indazoles under transition-metal-free conditions was developed. A series of substrates were tested showing eminent functional group tolerance and affording the C–N functionalization products in good to excellent yields. Mechanism studies revealed that a radical process was involved in this transformation.