Phosgene‐Free Carbonyl Insertion: Hot Advances in 11C‐Chemistry. Issue 3 (3rd December 2020)

• Record Type: Journal Article
• Authors: Bow, John‐Paul J.; Riss, Patrick J.
• Is Part Of: Chemistry methods. Volume 1:Issue 3(2020)
• Page Start: 139
• Page End: 141
• Publication Date: 2020-12-03
• Subjects: carbon-11 -- [11C]carbon dioxide -- carbonyl insertion reactions -- radiochemistry -- radiosynthesis; Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1002/cmtd.202000029
• Languages: English
• ISSNs: 2628-9725

Abstract

Abstract: Synthetic methods for carbon‐11 chemistry are highlighted with particular importance put on the activation of [ 11 C]CO2 . Methods focus on practical, alternative routes to key intermediates for synthesis of radiotracers without the reliance on [ 11 C]phosgene. Recent advances display practical syntheses with efficient total synthesis times and high molar activity in final products. Advances include the use of carbonyl transfer agents, transition‐metal catalysts, and functional groups in starting materials. Abstract : Glowing hot : Recent highlights of [ 11 C]CO2 radiolabelling without the use of [ 11 C]phosgene are reviewed and discussed.