Tissue engineered poly(caprolactone)‐chitosan‐poly(vinyl alcohol) nanofibrous scaffolds for burn and cutting wound healing. Issue 2 (1st June 2014)

• Record Type: Journal Article
• Authors: Gholipour‐Kanani, Adeleh; Bahrami, S. Hajir; Joghataie, Mohammad Taghi; Samadikuchaksaraei, Ali; Ahmadi‐Taftie, Hossein; Rabbani, Shahram; Kororian, Alireza; Erfani, Elham
• Is Part Of: IET nanobiotechnology. Volume 8:Issue 2(2014)
• Page Start: 123
• Page End: 131
• Publication Date: 2014-06-01
• Subjects: biomedical materials -- cellular biophysics -- nanoparticles -- patient treatment -- polymer blends -- skin -- tissue engineering -- wounds -- electrospinning -- hydrophobicity -- nanofibres -- nanomedicine; tissue engineering -- poly(caprolactone) -- poly(vinyl alcohol) -- PCL‐chitosan‐PVA blend nanofibrous scaffold -- burn wound healing -- cutting wound healing -- natural‐synthetic blend nanofibre -- electrospun -- PCL‐chitosan‐PVA mass ratio -- web hydrophobicity -- aqueous media -- mesenchymal stem cell -- rat dorsum skin -- wound area measurement -- cell‐seeded nanofibrous scaffold -- acellular scaffold formation; Biotechnology -- Periodicals; Nanotechnology -- Periodicals; 660.6
• DOI: 10.1049/iet-nbt.2012.0050
• Languages: English
• ISSNs: 1751-8741

Abstract

Abstract : Natural‐synthetic blend nanofibres have recently attracted more interest because of the ability of achieving desirable properties. Poly(ε‐caprolactone) (PCL)‐chitosan (Cs)‐poly(vinyl alcohol) (PVA) blend nanofibrous scaffolds were electrospun in 2:1:1.33 mass ratio of PCL:Cs:PVA. The presence of PCL in the blend leads to improvement in web hydrophobicity and helped the web to retain its integrity in aqueous media. The scaffolds were used in two forms of acellular and with mesenchymal stem cells. They were applied on burn ( n = 12) and excisional cutting ( n = 12) wounds on dorsum skin of rats. Macroscopic investigations were carried out to measure the wounds areas. It was found that the area of wounds that were treated with cell‐seeded nanofibrous scaffolds were smaller compared to other samples. Pathological results showed much better healing performance for cell‐seeded scaffolds followed by acellular scaffolds compared with control samples. All these results indicate that PCL:Cs:PVA nanofibrous web would be a proper material for burn and cutting wound healing.