Controlling fibroblast adhesion and proliferation by 1D Al2 O3 nanostructures. Issue 6 (4th July 2019)

• Record Type: Journal Article
• Authors: Aktas, Oral Cenk; Metzger, Wolfgang; Mees, Lisa; Martinez, Marina Miro; Haidar, Ayman; Oberringer, Martin; Wennemuth, Gunther; Pütz, Norbert; Ghori, Muhammad Zubair; Pohlemann, Tim; Veith, Michael
• Is Part Of: IET nanobiotechnology. Volume 13:Issue 6(2019)
• Page Start: 621
• Page End: 625
• Publication Date: 2019-07-04
• Subjects: biomechanics -- adhesion -- surface chemistry -- biomedical materials -- cellular biophysics -- surface topography -- nanostructured materials -- alumina -- nanomedicine; fibrotic encapsulation -- medical devices -- surface chemistry -- human fibroblasts -- surface topography -- cell size -- cell number -- well‐defined actin fibres -- focal adhesions -- distribution density -- fibroblast adhesion -- 1D nanostructures -- distribution densities -- fibroblast proliferation -- fibroblast‐surface interaction -- one‐dimensional aluminium oxide nanostructures -- Al2 O3; Biotechnology -- Periodicals; Nanotechnology -- Periodicals; 660.6
• DOI: 10.1049/iet-nbt.2018.5088
• Languages: English
• ISSNs: 1751-8741

Abstract

Abstract : The fibrotic encapsulation, which is mainly accompanied by an excessive proliferation of fibroblasts, is an undesired phenomenon after the implantation of various medical devices. Beside the surface chemistry, the topography plays also a major role in the fibroblast–surface interaction. In the present study, one‐dimensional aluminium oxide (1D Al2 O3 ) nanostructures with different distribution densities were prepared to reveal the response of human fibroblasts to the surface topography. The cell size, the cell number and the ability to form well‐defined actin fibres and focal adhesions were significantly impaired with increasing distribution density of the 1D Al2 O3 nanostructures on the substratum.