Entrapment of collagen on polylactic acid 3D scaffold surface as a potential artificial bone replacement. (2021)

• Record Type: Journal Article
• Authors: Hamzah, Mohd Syahir Anwar; Ng, Celine; Zulkarnain, Nur Ismalis Shafeqa; Majid, Huda A.; Razak, Saiful Izwan Abd; Nayan, Nadirul Hasraf Mat
• Is Part Of: Materials today. Volume 46:Part 4(2021)
• Page Start: 1668
• Page End: 1673
• Publication Date: 2021
• Subjects: 3D Printing -- Bone tissue replacement -- Polylactic acid -- Collagen -- Hydroxyapatite; Materials science -- Congresses -- Periodicals; 620.1
• DOI: 10.1016/j.matpr.2020.07.263
• Languages: English
• ISSNs: 2214-7853

Abstract

Abstract: A new potential biomimetic polymeric 3D scaffold is fabricated using collagen entrapment and 3D printed polylactic acid scaffold. The modified scaffold was characterized by compressive modulus, degree of swelling, water contact angle (WCA), and Fourier Transform Infrared Spectroscopy (FTIR). The findings show that sample PLA/col40 with 40 s entrapment duration is the optimum composition that meets the requirement for artificial bone tissue replacement. In vitro biomineralization using simulated body fluid (SBF) demonstrates that the PLA/collagen 3D scaffold is able to promote the growth of hydroxyapatite (HA) after 7 days which will subsequently improve the osteoconductive and osteoinductive properties of the 3D scaffold. The overall results suggest the potential of the 3D PLA/collagen scaffold as a prospective material for bone tissue engineering applications.