COVID-19-associated pulmonary aspergillosis in a Japanese man: A case report. Issue 6 (June 2021)

• Record Type: Journal Article
• Authors: Imoto, Waki; Himura, Hoshi; Matsuo, Kenji; Kawata, Sae; Kiritoshi, Ayako; Deguchi, Ryo; Miyashita, Masahiro; Kaga, Shinichiro; Noda, Tomohiro; Yamamoto, Katsumi; Yamada, Koichi; Uchida, Kenichiro; Nishimura, Tetsuro; Yamamoto, Hiromasa; Mizobata, Yasumitsu; Kakeya, Hiroshi
• Is Part Of: Journal of infection and chemotherapy. Volume 27:Issue 6(2021)
• Page Start: 911
• Page End: 914
• Publication Date: 2021-06
• Subjects: Coronavirus disease -- COVID-19-Associated pulmonary aspergillosis -- Invasive pulmonary aspergillosis; ARDS acute respiratory distress syndrome -- AZM azithromycin -- BAL bronchoalveolar lavage -- CAPA COVID-19 associated pulmonary aspergillosis -- COPD chronic obstructive pulmonary disease -- COVID-19 coronavirus disease -- CT computed tomography -- DEXA dexamethasone -- IPA invasive pulmonary aspergillosis -- SARS-CoV-2 severe acute respiratory syndrome coronavirus 2; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2021.02.026
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: CAPA (COVID-19 associated pulmonary aspergillosis) is an important complication of COVID-19. It has been reported that the incidence of CAPA is as high as 19%–33% worldwide. However, its onset has not been reported in Japan. A 72-year-old Japanese man was diagnosed with COVID-19 and was transferred to our hospital due to deterioration of respiratory condition. Treatment with remdesivir, dexamethasone (DEXA), and antibiotics was performed under mechanical ventilation. Although the condition improved temporarily, a new shadow appeared in the lung, and Aspergillus fumigatus was cultured from sputum. The patient was clinically diagnosed with CAPA and treated with voriconazole. However, his progress deteriorated and he died. High-risk COVID-19 patients should be tested for Aspergillus to ensure early diagnosis of CAPA.