Effects of CRRT on renal function and toxin clearance in patients with sepsis: a case–control study. Issue 9 (September 2021)

• Record Type: Journal Article
• Authors: Wang, Jinzhong; Wu, Zhongyong; Wen, Quan; Wang, Xiaozhi
• Is Part Of: Journal of international medical research. Volume 49:Issue 9(2021)
• Publication Date: 2021-09
• Subjects: Acute kidney injury -- survival -- mortality rate -- toxin -- Acute Physiology Chronic Health Evaluation II -- Sequential Organ Failure Assessment -- C-reactive protein -- tumor necrosis factor alpha; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/03000605211042981
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: To explore the effects of continuous renal replacement therapy (CRRT) on renal function and toxin clearance in patients with sepsis and concurrent acute kidney injury (AKI). Method: A retrospective analysis was performed using the medical records of 115 patients with sepsis and AKI. Among them, 60 patients received routine treatment (group A) and 55 patients received CRRT plus routine treatment (group B). Result: After treatment, the clearance rates of serum creatinine, lactic acid, and urea nitrogen were significantly lower in group A than in group B. The decrease in high-sensitivity C-reactive protein and tumor necrosis factor-α levels after treatment was significantly higher in group B than in group A. For the Acute Physiology Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) scores from the two groups, the scores were significantly lower in group B than in group A. The mortality rate within 28 days was significantly higher in group A than in group B. Conclusion: CRRT can effectively improve the condition of patients with sepsis and AKI, promote elimination of toxins (serum creatinine, lactic acid, and urea nitrogen) from the body, and reduce the mortality rate.