Se-mediated one-pot synthesis of 2-substituted benzoselenazole derivatives from 2 to iodoanilines and arylacetic acids/arylmethyl chlorides. Issue 29 (18th July 2018)

• Record Type: Journal Article
• Authors: Gu, Ren; Wang, Xin; Yang, Zhao; Han, Shiqing
• Is Part Of: Tetrahedron letters. Volume 59:Issue 29(2018)
• Page Start: 2835
• Page End: 2838
• Publication Date: 2018-07-18
• Subjects: Benzoselenazoles -- 2-Iodoanilines -- Selenium powder -- Synthetic methods; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.06.027
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: One-pot synthesis of 2-substituted benzoselenazole derivatives. An efficient three-component reaction. The method is free of the addition of ligand or additive. Abstract: A general approach to the formation of 2-substituted benzoselenazoles from the three-component reactions of 2-iodoanilines, selenium powder, arylacetic acids or benzyl chlorides is described. The use of copper salt as catalyst and dimethyl sulfoxide (DMSO) as solvent are crucial to afford the title compounds in moderate to good yields (45–88%) with good functional group tolerance on the aromatic and heteroaromatic substrates.