18F-Fluorocholine PET/CT Imaging of Brown Tumors in a Patient With Severe Primary Hyperparathyroidism. (December 2019)

• Record Type: Journal Article
• Authors: Zhang-Yin, Jules; Gaujoux, Sébastien; Delbot, Thierry; Gauthé, Mathieu; Talbot, Jean-Noël
• Is Part Of: Clinical nuclear medicine. Volume 44:Number 12(2019)
• Publication Date: 2019-12
• Subjects: 18F-fluorocholine -- PET/CT -- 99mTc-MIBI -- primary hyperparathyroidism -- brown tumors; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002814
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Brown tumors are rare skeletal anomalies occurring in patients with hyperparathyroidism and exposing patients to pathological fractures. We report the case of a 26-year-old woman with severe primary hyperparathyroidism (calcemia, 2.9 mmol/L; parathyroid hormone, 59 pmol/L) who underwent 18 F-fluorocholine (FCH) PET/CT before parathyroidectomy. FCH PET localized the hyperfunctioning parathyroid gland and showed multiple foci in correspondence with bone lytic lesions on CT. Those lesions were not visible on the 99m Tc-MIBI dual-phase scintigraphy. The pathology of one of the FCH-positive bone lesions corresponded to a brown tumor related to hyperparathyroidism.