Risk factors for biopsy complications in initial versus subsequent biopsies in native and transplant kidneys. (October 2021)

• Record Type: Journal Article
• Authors: Peters, Björn; Afghahi, Henri; Maitlo, Salar; Hadimeri, Henrik
• Is Part Of: Acta radiologica. Volume 62:Number 10(2021)
• Page Start: 1426
• Page End: 1432
• Publication Date: 2021-10
• Subjects: Blood pressure -- chronic kidney disease -- clinical nephrology -- renal biopsy -- transplantation; Radiology, Medical -- Periodicals; Radiography, Medical -- Periodicals; Radiotherapy -- Periodicals; 616.0757
• DOI: 10.1177/0284185120966687
• Languages: English
• ISSNs: 0284-1851

Abstract

Background: Few studies exist about risk factors for complications in subsequent biopsies. Purpose: To explore risk factors for complications in initial versus subsequent biopsies in native and transplant kidneys, which may predict biopsy complications. Material and Methods: In a multicenter study, 2830 native kidney biopsies (4.3% subsequent) were analyzed for major complications (1251 of these were also analyzed for minor) and 667 transplant kidney biopsies (29% subsequent) were analyzed for major and minor complications. No death or nephrectomy were described. Fisher's exact test, Student's t-test, chi-square analyses, and univariate and multiple binary logistic regression analyses were employed; P < 0.05 was considered significant. Results: In initial native kidney biopsies, the frequency of major complications was higher in women compared to men (odds ratio 1.6, 95% confidence interval 1.1–2.2), in younger patients (50 vs. 54 years, P = 0.007), and in patients with lower weight (78 vs. 82 kg, P = 0.005). In subsequent native kidney biopsies, patients with major complications had a higher systolic blood pressure (145 vs. 132 mmHg, P = 0.03). In initial transplant kidney biopsies, biopsies with major complications had less glomeruli in the biopsy (17 vs. 24, P = 0.046). In subsequent transplant kidney biopsies, patients with major complications had a higher mean arterial pressure (112 vs. 98 mmHg, P = 0.002). In subsequent native kidney biopsies, there was a higher number of SLE-nephritis (12% vs. 4.6%, P = 0.001) compared to initial biopsies. Conclusion: The different types of risk factors for complications in initial versus subsequent renal biopsies could be important for the clinicians to improve patients' safety.