Cross-sectional analysis of pulsatile hemodynamics across the adult life span: reference values, healthy and early vascular aging. Issue 12 (December 2019)

• Record Type: Journal Article
• Authors: Weber, Thomas; Wassertheurer, Siegfried; Hametner, Bernhard; Moebus, Susanne; Pundt, Noreen; Mahabadi, Amir A.; Roggenbuck, Ulla; Lehmann, Nils; Jöckel, Karl-Heinz; Erbel, Raimund
• Is Part Of: Journal of hypertension. Volume 37:Issue 12(2019:Dec.)
• Publication Date: 2019-12
• Subjects: arterial stiffness -- early vascular aging -- healthy vascular aging -- pulsatile hemodynamics -- pulse pressure -- wave reflections; Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/HJH.0000000000002178
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Background: Pulsatile hemodynamics predict major cardiovascular events. We aimed to provide comprehensive population-based reference values and to compare different measures of pulsatile hemodynamics to define early vascular aging (EVA) as well as healthy vascular aging (HVA). Methods: In 2721 participants from the population-based Heinz Nixdorf Recall Study and the associated MultiGeneration Study, free from diabetes, cardiovascular disease, and antihypertensive drugs, we performed high-fidelity radial tonometry, calibrated waveforms with brachial blood pressures and processed them with a validated transfer function, pulse wave analysis, and wave separation analysis. Aortic pulse wave velocity (aoPWV) was estimated with a validated regression formula. HVA was defined as the lowest, EVA as the highest age-specific decile of central pulse pressure (cPP), backward wave amplitude, and aoPWV. Results: Overall, 56.4% of participants were female, age range 18–90 years. Brachial PP increased from middle age, whereas cPP increased across the entire adult life span. Wave reflections increased across all age groups, apart from a plateau in older male participants. Indices of wave reflection were higher in women than in men. AoPWV showed the most prominent rise with age in both sexes. EVA and HVA, defined by cPP and backward wave amplitude, differed mainly by hemodynamic variables. In contrast, EVA participants were characterized by a worse hemodynamic, anthropometric, metabolic, and inflammatory profile, if aoPWV was used to discriminate EVA and HVA. Conclusion: Age-specific and sex-specific reference values for central pulsatile hemodynamics in a general white population cohort are provided and may be utilized to define HVA and EVA. Abstract : Supplemental Digital Content is available in the text