Breaching the phagosome, the case of the tuberculosis agent. (13th May 2021)

• Record Type: Journal Article
• Authors: Simeone, Roxane; Sayes, Fadel; Lawarée, Emeline; Brosch, Roland
• Other Names: Hartland Elizabeth guestEditor.
• Is Part Of: Cellular microbiology. Volume 23:Number 7(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-13
• Subjects: Microbiology -- Periodicals; Cytology -- Periodicals; Host-parasite relationships -- Periodicals; Microbiology -- Periodicals; Cells -- Periodicals; Microbiologie -- Périodiques; Microbiologie; Relation hôte-parasite; Cytologie; Cellule; Réponse cellulaire; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); 579.05
• DOI: 10.1111/cmi.13344
• Languages: English
• ISSNs: 1462-5814

Abstract

Abstract: The interactions between microbes and their hosts are among the most complex biological phenomena known today. The interaction may reach from overall beneficial interaction, as observed for most microbiome/microbiota related interactions to interaction with virulent pathogens, against which host cells have evolved sophisticated defence strategies. Among the latter, the confinement of invading pathogens in a phagosome plays a key role, which often results in the destruction of the invader, whereas some pathogens may counteract phagosomal arrest and survive by gaining access to the cytosol of the host cell. In the current review, we will discuss recent insights into this dynamic process of host‐pathogen interaction, using Mycobacterium tuberculosis and related pathogenic mycobacteria as main examples. Abstract : The genome of Mycobacterium tuberculosis, the causative agent of human tuberculosis, harbors two loci (ESX‐1 and DIM/PDIM), whose gene products are essential for the bacterium's ability to induce phagosomal rupture, when ingested by host phagocytes. The access to the host cytosol leads to important cellular signaling events and immune reactions.