Dissociation of humoral and cellular immune responses in kidney transplant recipients with EBV mucocutaneous ulcer. Issue 3 (4th January 2021)

• Record Type: Journal Article
• Authors: Isnard, Pierre; Bruneau, Julie; Sberro‐Soussan, Rebecca; Wendum, Dominique; Legendre, Christophe; Molina, Thierry; Chatenoud, Lucienne; Hermine, Olivier; Rossignol, Julien
• Is Part Of: Transplant infectious disease. Volume 23:Issue 3(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-01-04
• Subjects: dissociated immune response -- EBV positive mucocutaneous ulcer -- Epstein‐Barr virus -- Post‐transplant lymphoproliferative disorder; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.13552
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: EBV‐positive mucocutaneous ulcer (EBV‐MCU) is a rare EBV‐positive B‐cell lymphoproliferative disorder occurring in immunocompromised patients such as patients with solid organ or hematopoietic stem cells transplantation. EBV‐MCU often consists of an isolated and circumscribed cutaneous or mucosal ulcerative lesion with a self‐limited growth potential and a high regression rate upon immunosuppressive treatment withdrawal or rituximab therapy. Nevertheless, the pathophysiology of this latent infection leading to clonal lymphoproliferation is not well established. We report here two cases of EBV‐MCU in kidney transplant recipients with a dissociated immune response to EBV with the absence of EBV‐related antibodies and a positive T‐cell response to EBV suggesting a potential specific oncogenic mechanism in this lymphoproliferative disorder.