Telencephalon‐specific Alkbh1 conditional knockout mice display hippocampal atrophy and impaired learning. Issue 12 (19th May 2021)

• Record Type: Journal Article
• Authors: Kawarada, Layla; Fukaya, Masahiro; Saito, Ryo; Kassai, Hidetoshi; Sakagami, Hiroyuki; Aiba, Atsu
• Editors: Mantei, Ned
• Is Part Of: FEBS letters. Volume 595:Issue 12(2021)
• Page Start: 1671
• Page End: 1680
• Publication Date: 2021-05-19
• Subjects: Alkbh1 -- hippocampus -- knockout mice -- learning and memory -- mitochondria; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.14098
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : AlkB homolog 1 (ALKBH1) is responsible for the biogenesis of 5‐formylcytidine (f 5 C) on mitochondrial tRNA Met and essential for mitochondrial protein synthesis. The brain, especially the hippocampus, is highly susceptible to mitochondrial dysfunction; hence, the maintenance of mitochondrial activity is strongly required to prevent disorders associated with hippocampal malfunction. To study the role of ALKBH1 in the hippocampus, we generated dorsal telencephalon‐specific Alkbh1 conditional knockout (cKO) mice in inbred C57BL/6 background. These mice showed reduced activity of the respiratory chain complex, hippocampal atrophy, and CA1 pyramidal neuron abnormalities. Furthermore, performances in the fear‐conditioning and Morris water maze tests in cKO mice indicated that the hippocampal abnormalities led to impaired hippocampus‐dependent learning. These findings indicate critical roles of ALKBH1 in the hippocampus. Abstract :