The potential of cord blood to replenish young immune cells against cancer. Issue 1 (20th June 2021)

• Record Type: Journal Article
• Authors: Li, Xiaoyang; Cheng, Lin; Li, Junmin; Ren, Ruibao
• Is Part Of: Aging and cancer. Voume 2:Issue 1/2(2021)
• Page Start: 36
• Page End: 44
• Publication Date: 2021-06-20
• Subjects: Immune senescence -- Cord blood -- Aging -- Cancer; Cancer -- Age factors -- Periodicals; Geriatric oncology -- Periodicals; Electronic journals; Periodicals; 616.994
• DOI: 10.1002/aac2.12032
• Languages: English
• ISSNs: 2643-8909

Abstract

Abstract: The immune system of elderly individuals behaves differently from young adults, leading to a general assumption that the decline of immune system function increases the susceptibility to infectious and noninfectious diseases. This age‐related internal immune function failure, termed "immune senescence, " contributes to the increment of morbidity and mortality associated with diseases in elderly populations. Cord blood is considered as a source of "young" immune cells for anti‐infectious immunity and adoptive cancer immunotherapy. In this review, we describe immune aging and the application of cord blood for replenishing aging immune cells against neoplastic diseases. Abstract : Cancer incidence increases when people get older, which is associated with immune senescence. In this review, the authors firstly summarize the current progress about senescence of innate immune cells and acquired immune cells, such as a dendritic cell (DC), natural killer cell (NK), T cell, and B cell. Then, young immune cells, including hematopoietic stem cells, replenished by cord blood with or without genetic modification against malignant cancer, such as acute myeloid leukemia, and nonmalignant disease are introduced. Beyond that, transplantation of umbilical cord blood to rejuvenate the immune system is further discussed.