Denudatine-type diterpenoid alkaloids from an aqueous extract of the lateral root of Aconitum carmichaelii. Issue 7 (28th June 2021)

• Record Type: Journal Article
• Authors: Liu, Hui; Shao, Shuai; Xia, Huan; Wu, Yu-Zhuo; Zhu, Cheng-Gen; Xu, Cheng-Bo; Zhang, Tian-Tai; Guo, Qing-Lan; Shi, Jian-Gong
• Is Part Of: Journal of Asian natural products research. Volume 23:Issue 7(2021)
• Page Start: 615
• Page End: 626
• Publication Date: 2021-06-28
• Subjects: Ranunculaceae -- Aconitum carmichaelii -- C20-diterpenoid alkaloid -- denudatine derivative -- aconicarnines A − E; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.1931141
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Five new denudatine-type diterpenoid alkaloids (1–5), along with the known analogue aconicarmine (6 ), were isolated from an aqueous decoction of the lateral roots of Aconitum carmichaelii (fu-zi). Their structures were determined by spectroscopic data analysis and electronic circular dichroism (ECD) calculations. Compound 5 is the first denudatine-type diterpenoid alcohol iminium alkaloid, which could be partially transformed into the aza acetal form in pyridine- d 5 . Compound 5 inhibited mice writhing in an acetic acid-induced writhing assay. Graphical Abstract: UF0001