The efficacy and safety of DermalaxTM DEEP in the correction of moderate to severe nasolabial folds: a multicenter, randomized, double-blind clinical study. (4th July 2021)

• Record Type: Journal Article
• Authors: Qiao, Ju; Li, Feng; Jin, Hong-Zhong; Yang, Xiu-Min; Fang, Hong; Li, Li; Zhang, Wei; Wu, Xin-Feng; Zheng, Min; Jia, Qian-Nan
• Is Part Of: Journal of dermatological treatment. Volume 32:Number 5(2021)
• Page Start: 548
• Page End: 555
• Publication Date: 2021-07-04
• Subjects: Filler -- hyaluronic acid -- nasolabial fold -- clinical trial; Skin -- Diseases -- Treatment -- Periodicals; Skin Diseases -- drug therapy -- Periodicals; Skin Diseases -- therapy -- Periodicals; 616.5
• DOI: 10.1080/09546634.2019.1687814
• Languages: English
• ISSNs: 0954-6634

Abstract

Abstract: Background: To investigate the efficacy and safety of Dermalax in the correction of moderate to severe nasolabial folds (NLFs) compared to Restylane. Methods: A total of 324 subjects with moderate to severe NLFs were enrolled in this multicenter, randomized, double-blind, active-controlled clinical study. Eligible subjects were randomly assigned to the test group received Dermalax injection ( n = 162) or control group received Restylane injection ( n = 162). Clinical efficacy and safety were assessed based on the Wrinkle Severity Rating Scale (WSRS) and the Global Esthetic Improvement Scale(GAIS) at weeks 2, 8, 16, 24, 36 and 48 weeks after injection. Results: At week 24, similar improvements of effective rate were obtained on the Dermalax group (93.75%) and Restylane group (89.44%). Significances were found at 36 weeks and 48 weeks after injection, Dermalax seemed be better than Restylane in maintaining the effect in the later period. The improvement of mean WSRS score for test group was superior to that of control group with significance. GAIS scores rated at week 24 were 1.65 VS 1.94 ( p < .001) and 2.10 VS 2.27 ( p = .060), seperately. Conclusions: Dermalax was no inferior to or better than that of the control filler Restylane in correcting of moderate to severe NLFs in Chinese subjects.