Regioselective C–H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions. Issue 24 (28th May 2021)

• Record Type: Journal Article
• Authors: Liu, Xiang; Song, Dan; Zhang, Zemin; Lin, Jiatong; Zhuang, Canzhan; Zhan, Haiying; Cao, Hua
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 24(2021)
• Page Start: 5284
• Page End: 5288
• Publication Date: 2021-05-28
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob00701g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient and straightforward metal-free regioselective C–H dithiocarbamation of indolizines with tetraalkylthiuram disulfide has been described. A series of indolizines-dithiocarbamates derivatives were easily accessed in good yields. Abstract : An efficient and straightforward metal-free regioselective C–H dithiocarbamation of indolizines with tetraalkylthiuram disulfide has been described. A series of indolizine-dithiocarbamate derivatives were easily accessed in moderate to good yields with a broad scope. In addition, imidazo[1, 2- a ]pyridines were also well tolerated to afford diverse imidazoheterocycle-dithiocarbamate products, which are expected to be utilized for drug discovery. Of note, the reaction could be readily scaled up, and shows its practical value in organic synthesis.