Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods. Issue 34 (9th June 2021)

• Record Type: Journal Article
• Authors: Shi, Zhen; Wang, Yazhen; Dong, Shaobo; Lan, Tianyu
• Is Part Of: RSC advances. Volume 11:Issue 34(2021)
• Page Start: 20670
• Page End: 20678
• Publication Date: 2021-06-09
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra04256d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Roadmap for the synthesis of Fe3 O4 –PVA@SH using the step-by-step method and one-pot method. Abstract : In this paper, two methods were used to prepare the magnetic targeting drug carrier Fe3 O4 –PVA@SH, the step-by-step method and the one-pot method. The loading and release properties of the compound were measured. The results show that the Fe3 O4 –PVA@SH prepared using both methods exhibited excellent drug delivery properties in an environment that simulates human body fluid (pH 7.2) and a lysosomal in vitro simulation (pH 4.7). In applications such as drug delivery, magnetic targeted drug carriers prepared by both methods demonstrated superparamagnetism, high fat solubility, high hydroxyl content, and good water solubility.