Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic Diseases. (25th October 2011)

• Record Type: Journal Article
• Authors: Scotece, Morena; Conde, Javier; Gómez, Rodolfo; López, Veronica; Lago, Francisca; Gómez-Reino, Juan Jesus; Gualillo, Oreste
• Other Names: Fantuzzi Giamila Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 11(2011)
• Page Start: 1932
• Page End: 1947
• Publication Date: 2011-10-25
• Subjects: white adipose tissue (WAT) -- adipokines -- cytokines -- rheumatic diseases -- immune response -- immune tolerance -- metabolism -- energetic homeostasis; Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/2011/290142
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : The cloning of leptin in 1994 by Zhang et al. introduced a novel concept about white adipose tissue (WAT) as a very dynamic organ that releases a plethora of immune and inflammatory mediators, such as adipokines and cytokines, which are involved in multiple diseases. Actually, adipokines exert potent modulatory actions on target tissues involved in rheumatic diseases including cartilage, synovial, bone and immune cells. The goal of this paper is to elucidate the recent findings concerning the involvement of adipokines in rheumatic diseases, such as rheumatoid arthritis (RA), osteoarthritis (OA), and systemic lupus erythematosus (SLE).