Lack of Association Between the S83I ParC Mutation in Mycoplasma genitalium and Treatment Outcomes Among Men Who Have Sex With Men with Nongonococcal Urethritis. Issue 12 (December 2019)

• Record Type: Journal Article
• Authors: Chambers, Laura C.; Jensen, Jørgen S.; Morgan, Jennifer L.; Lowens, M. Sylvan; Romano, Sarah S.; Totten, Patricia A.; Soge, Olusegun O.; Hughes, James P.; Golden, Matthew R.; Manhart, Lisa E.
• Is Part Of: Sexually transmitted diseases. Volume 46:Issue 12(2019)
• Publication Date: 2019-12
• Subjects: Sexually transmitted diseases -- Periodicals; Sexual health -- Periodicals; 616.951005
• DOI: 10.1097/OLQ.0000000000001035
• Languages: English
• ISSNs: 0148-5717

Abstract

Abstract : Abstract: From February 2015 to October 2017, among 20 men who have sex with men with Mycoplasma genitalium -associated nongonococcal urethritis, 15% had macrolide resistance and S83I ParC mutations. Azithromycin followed by moxifloxacin cleared Mycoplasma genitalium in 2 of 2 with and 11 of 13 without S83I mutations. Dual failures were cleared after doxycycline. S83I mutations were not associated with moxifloxacin failure. Abstract : Among men who have sex with men with Mycoplasma genitalium -associated nongonococcal urethritis, the S83I ParC mutation was present in 15% but not associated with moxifloxacin treatment failure.