Three-Dimensional Printed Modeling of Diffuse Low-Grade Gliomas and Associated White Matter Tract Anatomy. Issue 4 (16th March 2017)

• Record Type: Journal Article
• Authors: Thawani, Jayesh P.; Singh, Nickpreet; Pisapia, Jared M.; Abdullah, Kalil G.; Parker, Drew; Pukenas, Bryan A.; Zager, Eric L.; Verma, Ragini; Brem, Steven
• Is Part Of: Neurosurgery. Volume 80:Issue 4(2017)
• Page Start: 635
• Page End: 645
• Publication Date: 2017-03-16
• Subjects: 3-D printing -- Brain tumor modeling -- Diffusion tensor imaging; Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1093/neuros/nyx009
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract: BACKGROUND: Diffuse low-grade gliomas (DLGGs) represent several pathological entities that infiltrate and invade cortical and subcortical structures in the brain. OBJECTIVE: To describe methods for rapid prototyping of DLGGs and surgically relevant anatomy. METHODS: Using high-definition imaging data and rapid prototyping technologies, we were able to generate 3 patient DLGGs to scale and represent the associated white matter tracts in 3 dimensions using advanced diffusion tensor imaging techniques. RESULTS: This report represents a novel application of 3-dimensional (3-D) printing in neurosurgery and a means to model individualized tumors in 3-D space with respect to subcortical white matter tract anatomy. Faculty and resident evaluations of this technology were favorable at our institution. CONCLUSION: Developing an understanding of the anatomic relationships existing within individuals is fundamental to successful neurosurgical therapy. Imaging-based rapid prototyping may improve on our ability to plan for and treat complex neuro-oncologic pathology.