Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?. (26th October 2011)

• Record Type: Journal Article
• Authors: Fretzayas, Andrew; Liapi, Olga; Papadopoulou, Anna; Nicolaidou, Polyxeni; Stamoulakatou, Alexandra
• Other Names: Wasmuth Hermann E. Academic Editor.
• Is Part Of: Case reports in medicine. Volume 2011(2011)
• Publication Date: 2011-10-26
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Case Reports; Periodicals; 610
• DOI: 10.1155/2011/730250
• Languages: English
• ISSNs: 1687-9627

Abstract

Abstract : Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated. We describe 3 children with ceftriaxone-induced pseudolithiasis, who were also carriers of the A(TA)7 TAA polymorphism of the UGT1A1 gene, implying that a cause and effect relation may exist.