HISTOLOGIC FINDINGS IN VITREORETINAL LYMPHOMA: Learning From Enucleation Specimens. Issue 2 (February 2020)

• Record Type: Journal Article
• Authors: Albadri, Sam T.; Pulido, Jose S.; Macon, William R.; Garcia, Joaquin J.; Salomao, Diva R.
• Other Names: Wilson David section editor.
• Is Part Of: Retina. Volume 40:Issue 2(2020)
• Publication Date: 2020-02
• Subjects: enucleation -- eye -- intraocular lymphoma -- lymphoma -- vitreoretinal lymphoma; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000002676
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: We aimed to describe the clinical and histologic findings in a few enucleation cases with intraocular lymphoma. Methods: Retrospective review of pathology files from a 22-year period identified cases with intraocular lymphoma among all enucleation specimens. Patient demographics, clinical findings, laboratory results, radiographic studies, and indication for enucleation were abstracted from electronic health records; slides were reviewed. Results: Four patients (three women and one man; age range, sixth through eighth decades of life) underwent enucleation with a final diagnosis of intraocular lymphoma. Two patients with primary vitreoretinal large B-cell lymphomas had been treated for refractory uveitis. Specimens showed retinal and subretinal infiltrates by atypical large B-lymphocytes and rare neoplastic cells in the vitreous. The remaining two patients had systemic lymphoproliferative disorders. One patient had chronic lymphocytic leukemia and floaters in his eye; vitreoretinal lymphoma developed, consistent with intraocular Richter transformation. The other had diffuse large B-cell lymphoma in remission; however, blurred vision developed, she was treated for panuveitis without improvement, and was later found to have ocular involvement by diffuse large B-cell lymphoma. Conclusion: Our series details the unusual circumstances when an eye is removed for intraocular lymphoma. Different patterns of ocular tissue involvement were observed when we compared primary and secondary lymphomas. Abstract : Intraocular lymphomas are a heterogeneous group of lymphoid neoplasms, characterized by diverse patterns according to the ocular tissue involved. Vitreoretinal lymphomas can present with predominantly retinal and subretinal space infiltrates and rare malignant cells in the vitreous. For cases of systemic lymphoma, the eye may function as a "sanctuary site."