A case report of an acute coronary syndrome in a 10-year-old boy with homozygous familial hypercholesterolaemia. Issue 1 (13th January 2020)

• Record Type: Journal Article
• Authors: Leclercq, Thibault; Falcon-Eicher, Sylvie; Farnier, Michel; Le Bret, Emmanuel; Maudinas, Raphaëlle; Litzler-Renault, Stéphanie; Mousson, Christiane; Lorgis, Luc; Cottin, Yves
• Editors: Toth, Gabor G; Janosi, Andras; Johnson, Thomas; Baghdasaryan, Lilit; Baboujian, Araz; Mukherjee, Rahul; Patel, Peysh A
• Is Part Of: European heart journal. Volume 4:Issue 1(2020)
• Page Start: 1
• Page End: 5
• Publication Date: 2020-01-13
• Subjects: Case report -- Homozygous familial hypercholesterolaemia -- Acute coronary syndrome -- LDL cholesterol; Cardiology -- Periodicals; Cardiology -- Case studies -- Periodicals; Heart -- Diseases -- Periodicals; Heart -- Diseases -- Case studies -- Periodicals; 616.12
• DOI: 10.1093/ehjcr/ytz233
• Languages: English
• ISSNs: 2514-2119

Abstract

Abstract: Background: Familial hypercholesterolaemia is a well-known disorder, but clinical diagnoses tend to be delayed. Acute coronary syndrome may occur in childhood. Case summary: Our patient, a young boy with homozygous familial hypercholesterolaemia, complained of persistent chest pain at rest and suffered a non-ST-elevation myocardial infarction (NSTEMI). The diagnosis of NSTEMI was made on the basis of his clinical features, dynamic electrocardiogram changes, troponin elevation, and cardiac computed tomography findings. The patient was managed surgically by intrathoracic artery (ITA) bypass graft. During post-operative follow-up, the young patient suffered from angina pectoris from unexpected and exceptional atheroma stenosis on the ITA. Discussion: Familial hypercholesterolaemia needs to be identified quickly in young patients and lipid lowering therapies should be started without delay.